Site card
Nanorobotic equipment
Where:
Center for Biomedical Technology
Ubicación:
Laboratorio de Bioinstrumentación y Nanomedicina, Centro de Tecnología Biomédica (CTB)
Typology:
Infraestructura Científica
Manager: José Javier Serrano Olmedo
Email:
It allows movement to be induced in magnetic nanoparticles, in order to cause damage to the cell in which they are internalised and thus destroy it. Its largest component is a permanent magnet, which provides an area of approximately 50 x 50 x 20 cm and has a homogeneously distributed magnetic field with an intensity of approximately 130 mT. It is in that space that a gradient coil, manufactured in the laboratory, is placed. We also use a water bath to insulate the sample holder from the heat produced in the coil, so that the results are not altered by that heat.
Health, Medicine. Development of anti-cancer technologies, although it could also be extended to other sectors.
The aim is to make progress in a novel approach to cancer treatment, whereby the movement of nanoparticles is intended to cause cell death. Positive results have been obtained in osteoblast cell lines. This approach aims to expand the cell types and standardise the procedures. We have the support of a group specialising in viability analysis, with which a great many experiments are being carried out. The aim is to destroy cancerous cells by inducing linear movement in magnetic nanoparticles. They are previously internalised in glioblastoma and melanoma cell lines. Later on, following positive results, they will be inoculated into laboratory mice.
It allows tests to be carried out that involve applying a magnetic field in different circumstances and, by means of cell viability analysis, assessing the damage caused to the cells.
Synergy with a similar technique that follows a different strategy: causing the nanoparticles to rotate instead of inducing linear movement, backwards and forwards, like a battering ram. We expect this type of movement to achieve sufficient destructive capacity and thus improve on that obtained by means of rotation.
